Citation

Tee, Sim Hui and Quek, Albert (2013) Identifying hsa-miR-122 target sites in HCV isolate JFH-1. In: 2013 IEEE Business Engineering and Industrial Applications Colloquium (BEIAC). IEEE Xplore, pp. 863-868. ISBN 978-1-4673-5967-2

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Abstract

MicroRNAs are short regulatory genes that regulate the gene expression in various cellular activities and pathways. Identification of microRNA target site is important for the understanding of pathogenesis and cellular functions. This study applies a computational approach to identify hsa-miR-122 target sites in hepatitis C virus isolate JFH-1. The minimum free energy, seed region complementarity, and 3' region complementarity were taken as the determining factors for the binding affinity. We have identified a total of four hsa-miR-122 target sites. The identified target sites can be used in therapy strategies and drug designs for hepatocellular carcinoma and hepatitis C.

Item Type:	Book Section
Subjects:	Q Science > QA Mathematics > QA71-90 Instruments and machines > QA75.5-76.95 Electronic computers. Computer science
Divisions:	Faculty of Computing and Informatics (FCI)
Depositing User:	Ms Suzilawati Abu Samah
Date Deposited:	20 Feb 2014 02:06
Last Modified:	21 Apr 2015 04:11
URII:	http://shdl.mmu.edu.my/id/eprint/5296

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