Citation

Mohd Nasir, N. and Lee, B. K. and Yap, Seong Shan and Thong, K. L. and Yap, Seong Ling (2016) Cold plasma inactivation of chronic wound bacteria. Archives of Biochemistry and Biophysics, 605. pp. 76-85. ISSN 0003-9861

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Abstract

Cold plasma is partly ionized non-thermal plasma generated at atmospheric pressure. It has been recognized as an alternative approach in medicine for sterilization of wounds, promotion of wound healing, topical treatment of skin diseases with microbial involvement and treatment of cancer. Cold plasma used in wound therapy inhibits microbes in chronic wound due to its antiseptic effects, while promoting healing by stimulation of cell proliferation and migration of wound relating skin cells. In this study, two types of plasma systems are employed to generate cold plasma: a parallel plate dielectric barrier discharge and a capillary-guided corona discharge. Parameters such as applied voltage, discharge frequency, treatment time and the flow of the carrier gas influence the cold plasma chemistry and therefore change the composition and concentration of plasma species that react with the target sample. Chronic wound that fails to heal often infected by multidrug resistant organisms makes them recalcitrant to healing. Methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa (Pseudomonas aeruginosa) are two common bacteria in infected and clinically non-infected wounds. The efficacies of the cold plasma generated by the two designs on the inactivation of three different isolates of MRSA and four isolates of P. aeruginosa are reported here.

Item Type:	Article
Uncontrolled Keywords:	Chronic wound bacteria inactivation; Cold plasma; Corona discharge; Dielectric barrier discharge; Non thermal plasma; Wound healing
Subjects:	Q Science > QC Physics > QC501-766 Electricity and magnetism > QC501-(721) Electricity > QC717.6-718.8 Plasma physics. Ionized gases
Divisions:	Faculty of Engineering (FOE)
Depositing User:	Ms Suzilawati Abu Samah
Date Deposited:	07 Dec 2017 14:10
Last Modified:	07 Dec 2017 14:10
URII:	http://shdl.mmu.edu.my/id/eprint/6580

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