Scalable Nuclei Detection in HER2-SISH Whole Slide Images via Fine-Tuned Stardist with Expert-Annotated Regions of Interest

Citation

Rehman, Zaka Ur and Ahmad Fauzi, Mohammad Faizal and Wan Ahmad, Wan Siti Halimatul Munirah and Abas, Fazly Salleh and Cheah, Phaik Leng and Chiew, Seow Fan and Looi, Lai Meng (2025) Scalable Nuclei Detection in HER2-SISH Whole Slide Images via Fine-Tuned Stardist with Expert-Annotated Regions of Interest. Diagnostics, 15 (13). p. 1584. ISSN 2075-4418

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Abstract

Breast cancer remains a critical health concern worldwide, with histopathological analysis of tissue biopsies serving as the clinical gold standard for diagnosis. Manual evaluation of histopathology images is time-intensive and requires specialized expertise, often resulting in variability in diagnostic outcomes. In silver in situ hybridization (SISH) images, accurate nuclei detection is essential for precise histo-scoring of HER2 gene expression, directly impacting treatment decisions.

Item Type: Article
Uncontrolled Keywords: Deep learning
Subjects: Q Science > Q Science (General) > Q300-390 Cybernetics
Divisions: Faculty of Engineering and Technology (FET)
Faculty of Artificial Intelligence & Engineering (FAIE)
Depositing User: Ms Rosnani Abd Wahab
Date Deposited: 29 Jul 2025 05:58
Last Modified: 01 Aug 2025 03:44
URII: http://shdl.mmu.edu.my/id/eprint/14385

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