Biologically active indole and bisindole alkaloids from Tabernaemontana divaricata


Kam, Toh-Seok and Pang, Huey-Shen and Lim, Tuck-Meng (2003) Biologically active indole and bisindole alkaloids from Tabernaemontana divaricata. Organic & Biomolecular Chemistry, 1 (8). pp. 1292-1297. ISSN 14770520

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The ethanol extract of the leaves of Tabernaemontana divaricata (double flower variety) provided a total of 23 alkaloids, including the new aspidosperma alkaloids, taberhanine, voafinine, N-methylvoafinine, voafinidine, voalenine and the new bisindole alkaloid, conophyllinine in addition to the previously known, biologically active bisindole, conophylline and its congener, conofoline. The structures of the new alkaloids were established by spectroscopic methods. The preparation and characterization of the corresponding quinones of the biologically active bisindoles are also described in relation to a structure-activity study of these compounds with respect to their action in stimulating insulin expression.

Item Type: Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Engineering and Technology (FET)
Depositing User: Ms Rosnani Abd Wahab
Date Deposited: 24 Aug 2011 01:34
Last Modified: 24 Aug 2011 01:34


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