Citation

Hamza, Musa N. and Islam, Mohammad Tariqul and Lavadiya, Sunil and ud Din, Iftikhar and Sanches, Bruno and Koziel, Slawomir and Naqvi, Syeda Iffat and Panda, Abinash and Alibakhshikenari, Mohammad and Virdee, Bal and Mariyanayagam, D. and Jayanthi, R. and Fernando, S. and Islam, Md. Shabiul (2025) A 50THz Ultra-Wideband Nano-Photonics Perfect Absorber Biosensor for Label-Free Detection of Circulating Cancer Exosomes: Advancing Early Cancer Diagnostics. IEEE Photonics Journal, 17 (4). pp. 1-16. ISSN 1943-0647

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Abstract

This paper addresses the challenge of early-stage cancer diagnosis using microwave imaging (MWI) techniques by targeting circulating exosomes, recently identified as promising cancer biomarkers. We introduce an innovative nano-photonic perfect absorber (NPA) operating in the terahertz (THz) range, offering a significant improvement over existing MWI-based approaches in terms of simplicity, sensitivity, and specificity. Unlike previous THz absorbers, the proposed NPA achieves an exceptionally wide operating bandwidth from 100 GHz to 50 THz with an absorption efficiency exceeding 97.5%, while featuring an ultra-compact nanoscale footprint (100 × 100 nm2, thickness 30 nm). The design integrates a silver (Ag) resonator and a nickel (Ni) ground plane on a silicon dioxide (SiO2) substrate, with meticulously tuned geometries to create multiple resonance modes, enabling continuous broadband absorption. Full-wave electromagnetic simulations validate the structure’s performance, including electric and magnetic field distributions, surface currents, and scattering parameters. Comparative analysis with state-of-the-art absorbers demonstrates the superior bandwidth, absorption stability, and angular robustness of our device. Furthermore, we demonstrate the NPA’s unique ability to act as a label-free biosensor for exosome detection, where cancerous exosomes consistently induce stronger electric field responses than normal exosomes due to their distinct molecular compositions. These results confirm the proposed NPA as a novel, highly effective platform for non-invasive, early-stage cancer diagnostics via MWI.

Item Type:	Article
Uncontrolled Keywords:	Nano-photonic perfect absorber (NPA), terahertz (THz) imaging, label-free exosome detection, ultra-wideband absorber, early cancer diagnostics.
Subjects:	T Technology > TK Electrical engineering. Electronics Nuclear engineering > TK7800-8360 Electronics > TK7871 Electronics--Materials
Divisions:	Faculty of Applied Communication (FAC)
Depositing User:	Ms Suzilawati Abu Samah
Date Deposited:	26 Jun 2025 06:11
Last Modified:	26 Jun 2025 06:11
URII:	http://shdl.mmu.edu.my/id/eprint/14083

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