Genomic diversity of SARS-CoV-2 in Malaysia


Mohamad Noordin, Noorliza and Tan, Joon Liang and Chong, Chee Kheong and Chem, Yu Kie and Tajudin, Norazimah and Abu Bakar, Rehan Shuhada and Sengol, Selvanesan and Phoon, Hannah Yik Phing and Che Azid, Nurul Aina Murni and W Mohd Arifin, W Nur Afiza and Aziz, Zirwatul Adilah and Hussin, Hani and Ibrahim, Nurul Syahida and Omar, Aziyati and Ravi, Ushananthiny and Kamarul Zaman, Kamal Hisham and Yamin, Mohd Asri and Ngeow, Yun Fong (2021) Genomic diversity of SARS-CoV-2 in Malaysia. PeerJ, 9. e12449. ISSN 2167-8359

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More than a year after its first appearance in December 2019, the COVID-19 pandemic is still on a rampage in many parts of the world. Although several vaccines have been approved for emergency use, the emergence and rapid spread of new SARS-CoV-2 variants have sparked fears of vaccine failure due to immune evasion. Massive viral genome sequencing has been recommended to track the genetic changes that could lead to adverse consequences. Methods We sequenced SARS-CoV-2 respiratory isolates from the National Public Health Laboratory, Malaysia and examined them together with viral genomes deposited in GISAID by other Malaysian researchers, to understand the evolutionary trend of the virus circulating in the country. We studied the distribution of virus lineages and site-wise mutations, analysed genetic clustering with the goeBURST full Minimum Spanning Tree algorithm, examined the trend of viral nucleotide diversity over time and performed nucleotide substitution association analyses.

Item Type: Article
Uncontrolled Keywords: SARS-CoV-2, Genetic diversity, Lineages, Mutations, Linkage disequilibrium
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Information Science and Technology (FIST)
Depositing User: Ms Nurul Iqtiani Ahmad
Date Deposited: 03 Dec 2021 06:38
Last Modified: 03 Dec 2021 06:38


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