Genome sequence analysis of multidrug-resistant Mycobacterium tuberculosis from Malaysia


Tan, Joon Liang and Simbun, Alfred and Chan, Kok Gan and Ngeow, Yun Fong (2020) Genome sequence analysis of multidrug-resistant Mycobacterium tuberculosis from Malaysia. Scientific Data, 7 (1). ISSN 2052-4463

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Mycobacterium tuberculosis (MtB) is commonly used as a model to study pathogenicity and multiple drug resistance in bacteria. these MtB characteristics are highly dependent on the evolution and phylogeography of the bacterium. In this paper, we describe 15 new genomes of multidrug-resistant MtB (MDRtB) from Malaysia. the assessments and annotations on the genome assemblies suggest that strain differences are due to lineages and horizontal gene transfer during the course of evolution. the genomes show mutations listed in current drug resistance databases and global MtB collections. this genome data will augment existing information available for comparative genomic studies to understand MtB drug resistance mechanisms and evolution

Item Type: Article
Uncontrolled Keywords: Computational biology and bioinformatics, Microbiology
Subjects: Q Science > QR Microbiology
Divisions: Faculty of Information Science and Technology (FIST)
Depositing User: Ms Rosnani Abd Wahab
Date Deposited: 09 Dec 2020 14:49
Last Modified: 09 Dec 2020 14:49


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