A sequential algorithm for the non-linear dual-sorption model of percutaneous drug absorption

Gumel, A. B. and Kubota, K. and Twizell, E. H. (1998) A sequential algorithm for the non-linear dual-sorption model of percutaneous drug absorption. Mathematical Biosciences, 152 (1). pp. 87-103. ISSN 0025-5564

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Abstract

A sequential algorithm is developed for the non-linear dual-sorption model developed by Chandrasekaran et al. 1 and 2 which monitors pharmacokinetic profiles in percutaneous drug absorption. In the experimental study of percutaneous absorption, it is often observed that the lag-time decreases with the increase in the donor concentration when two or more donor concentrations of the same compound are used. The dual-sorption model has sometimes been employed to explain such experimental results. In this paper, it is shown that another feature observed after vehicle removal may also characterize the dual-sorption model. Soon after vehicle removal, the plots of the drug flux versus time become straight lines on a semilogarithmic scale as in the linear model, but the half-life is prolonged thereafter when the dual-sorption model prevails. The initial half-life after vehicle removal with a low donor concentration is longer than that with a higher donor concentration. These features, if observed in experiments, may be used as evidence to confirm that the dual-sorption model gives an explanation to the non-linear kinetic behaviour of a permeant

Item Type: Article
Subjects: T Technology > T Technology (General)
Divisions: Faculty of Computing and Informatics (FCI)
Depositing User: Ms Nurul Iqtiani Ahmad
Date Deposited: 11 Sep 2013 08:03
Last Modified: 17 Feb 2014 01:54
URI: http://shdl.mmu.edu.my/id/eprint/3957

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